| Literature identifier | Study type | Test dosage | Effective dosage | Endocrine-mediated endpoints | Systems-level perturbations |
|---|---|---|---|---|---|
| PMID:17992702 | IVTH | 0.000001 M | 0.000001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:18940961 | IVR | 100 mg/kg | 100 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 30 mg/kg | 30 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 30 mg/kg | 30 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/kg | 3 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/kg | 3 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 300 mg/kg | 300 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg | 100 mg/kg | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| PMID:19118620 | IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased vas deferens weights | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 20 mg/kg/day | 20 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased vas deferens weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg/day | 10 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | - | No significant effects observed | - | |
| PMID:20562219 | IVR | 1.18 - 300 mg/kg | 18.8 - 150 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 1.18 - 300 mg/kg | 150 mg/kg | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 1.18 - 300 mg/kg | 150 mg/kg | Alterations in vaginal opening | Reproductive endocrine-mediated perturbations | |
| PMID:22677473 | IVTH | 0.000000001 - 0.0001 M | 0.0000001 - 0.0001 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.000000001 - 0.0001 M | 0.00005 - 0.0001 M | Increased hCG levels | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.000000001 - 0.0001 M | 0.000001 - 0.00001 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:23831729 | IVR | 75 mg/kg/day | 75 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:23929691 | IVR | 50 mg/kg | 50 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations |
| IVR | 200 mg/kg | 200 mg/kg | Abnormal sperm morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Affects developmental process | Developmental endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 10 mg/kg | - | No significant effects observed | - | |
| PMID:24684733 | IVTH | 0.0000001 - 0.00001 M | 0.000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| IVR | 100 mg/kg | 100 mg/kg | Induce tumor progression | Endocrine-mediated cancer | |
| IVR | 100 mg/kg | 100 mg/kg | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:24740835 | IVTH | 0.000000001 - 0.000001 M | 0.000001 M | Occurrence of mammary gland tumor | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations |
| PMID:24835555 | IVTH | 0.000000001 - 0.000001 M | 0.000000001 - 0.0001 M | Ovarian carcinoma | Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations |
| IVTH | 0.000000001 - 0.000001 M | 0.000000001 - 0.0001 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:25404284 | IVR | 15 mg/kg | 15 mg/kg | Hepatocellular carcinoma | Endocrine-mediated cancer;Hepatic endocrine-mediated perturbations |
| PMID:25554385 | IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Affects survival of live fetus | Reproductive endocrine-mediated perturbations |
| IVR | 0.05 mg/kg/day | 0.05 mg/kg/day | Changes in mammary gland morphology | Reproductive endocrine-mediated perturbations | |
| PMID:25642592 | IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Induce apoptosis of placental cells | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| PMID:25682003 | IVTH | 0.00000001 - 0.00001 M | 0.00000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer |
| PMID:26604029 | IVTH | 0.00000000001 M | 0.00000000001 M | Pregnancy complications | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000001 M | 0.00000001 M | Induced migration capability of tumor cells | Endocrine-mediated cancer | |
| IVTH | 0.00000001 M | 0.00000001 M | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Pregnancy complications | Reproductive endocrine-mediated perturbations | |
| PMID:27149376 | IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects expression of progesterone receptor (PR) | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects expression of androgen receptor (AR) | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased hCG levels | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects steroid metabolism | Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased prolactin levels | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased hCG levels | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 30 mg/kg/day | 30 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased hCG levels | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased prolactin levels | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Decreased hCG levels | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Increased uterine weights | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Decreased prolactin levels | Reproductive endocrine-mediated perturbations | |
| IVR | 600 mg/kg/day | 600 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased testosterone levels | Reproductive en | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Affects expression of androgen receptor (AR) | ||
| IVR | 300 mg/kg/day | 300 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) | ||
| IVR | 300 mg/kg/day | 300 mg/kg/day | Affects expression of progesterone receptor (PR) | ||
| IVR | 300 mg/kg/day | 300 mg/kg/day | Decreased progesterone levels | ||
| IVR | 300 mg/kg/day | 300 mg/kg/day | Affects steroid metabolism | ||
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased prolactin levels | ||
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testosterone levels | ||
| PMID:28096238 | IVTH | 0.000001 - 0.000005 M | 0.000001 - 0.00001 M | Affects differentiation process | Developmental endocrine-mediated perturbations |
| PMID:28569618 | IVR | 37.5 mg/kg | 37.5 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVR | 37.5 mg/kg | 37.5 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 9.38 mg/kg | 9.38 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 2.35 mg/kg | - | No significant effects observed | - | |
| IVR | 4.69 mg/kg | 4.69 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:29310425 | IVTH | 0.0000001 - 0.00001 M | 0.0000001 - 0.00001 M | Oxidative stress in liver | Hepatic endocrine-mediated perturbations |
| IVTH | 0.0000001 - 0.00001 M | 0.0000001 - 0.00001 M | Cancer phenotype | Endocrine-mediated cancer | |
| PMID:29323457 | IVR | 185 mg/kg | 185 mg/kg | Increased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVR | 185 mg/kg | 185 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 185 mg/kg | 185 mg/kg | Affects expression of estrogen receptor-alpha (ER-alpha) | Reproductive endocrine-mediated perturbations | |
| IVR | 185 mg/kg | 185 mg/kg | Increased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 185 mg/kg | 185 mg/kg | Increased FSH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 185 mg/kg | 185 mg/kg | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| PMID:29350491 | IVR | 50 mg/kg | 50 mg/kg | Affects uterine function | Reproductive endocrine-mediated perturbations |
| IVR | 50 mg/kg | 50 mg/kg | Affects superoxide dismutase (SOD) levels | Hepatic endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased prostate weights | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Alterations in number of leydig cells | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg | 50 mg/kg | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| PMID:29376079 | IVTH | 0.00000001 - 0.0001 M | 0.00000001 - 0.0001 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00000001 - 0.0001 M | 0.00000001 - 0.0001 M | Decreased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:29462796 | IVR | 100 mg/kg/day | 100 mg/kg/day | Affects thyroid function | Metabolic endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Oxidative stress in nervous system | Neurological endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Oxidative stress in nervous system | Neurological endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Increased liver weights | Hepatic endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Affects xenobiotic metabolism | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Oxidative stress in nervous system | Neurological endocrine-mediated perturbations | |
| PMID:29501854 | IVTH | 10 M | 10 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations |
| IVTH | 3 M | 3 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg | 200 mg/kg | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| IVTH | 1 M | - | No significant effects observed | - | |
| IVR | 50 mg/kg | - | No significant effects observed | - | |
| IVTH | 0.1 M | - | No significant effects observed | - | |
| IVTH | 0.3 M | - | No significant effects observed | - | |
| IVTH | 0.01 M | - | No significant effects observed | - | |
| PMID:30321646 | IVR | 8 mg/kg | 8 mg/kg | Affects uterine morphology | Reproductive endocrine-mediated perturbations |
| IVR | 0.8 mg/kg | - | No significant effects observed | - | |
| IVR | 2.4 mg/kg | - | No significant effects observed | - | |
| PMID:30415262 | IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 50 mg/kg/day | 50 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased LH levels | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations | |
| IVR | 200 mg/kg/day | 200 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations | |
| IVR | 100 mg/kg/day | 100 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| PMID:31240815 | IVR | 75 mg/kg/day | 75 mg/kg/day | Decrease in T3 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Affects uterine morphology in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Abnormal estrous cycles in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 75 mg/kg/day | 75 mg/kg/day | Decrease in T4 levels in offspring | Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Abnormal estrous cycles in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Affects uterine morphology in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Affects uterine morphology in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 300 mg/kg/day | 300 mg/kg/day | Abnormal estrous cycles in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| PMID:31780364 | IVR | 40 mg/kg/day | 40 mg/kg/day | Affects spermatogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Affects sperm motility in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Decreased testosterone levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Reduced sperm counts in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Affects implantation in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Affects steroidogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 40 mg/kg/day | 40 mg/kg/day | Changes in morphology of seminiferous tubules in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Decreased testosterone levels in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 0.1 mg/kg/day | 0.1 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Affects sperm motility in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Affects spermatogenesis in offspring | Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Decreased testosterone levels in offspring | D | |
| IVR | 150 mg/kg/day | 150 mg/kg/day | Reduced sperm counts in offspring | ||
| IVR | 150 mg/kg/day | 150 mg/kg/day | Affects steroidogenesis in offspring | ||
| IVR | 150 mg/kg/day | 150 mg/kg/day | Changes in morphology of seminiferous tubules in offspring | ||
| IVR | 150 mg/kg/day | 150 mg/kg/day | Affects implantation in offspring | ||
| IVR | 4 mg/kg/day | 4 mg/kg/day | Affects sperm motility in offspring | ||
| IVR | 4 mg/kg/day | 4 mg/kg/day | Affects expression of estrogen receptor-alpha (ER-alpha) in offspring | ||
| IVR | 4 mg/kg/day | 4 mg/kg/day | Affects steroidogenesis in offspring | ||
| IVR | 4 mg/kg/day | 4 mg/kg/day | Reduced sperm counts in offspring | ||
| IVR | 4 mg/kg/day | 4 mg/kg/day | Changes in morphology of seminiferous tubules in offspring | ||
| IVR | 4 mg/kg/day | 4 mg/kg/day | Decreased testosterone levels in offspring | ||
| PMID:32053938 | IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 3 - 5 mg/kg/day | 3 - 5 mg/kg/day | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 5 mg/kg/day | 5 mg/kg/day | Changes in testicular morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 3 - 5 mg/kg/day | 3 - 5 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 3 - 5 mg/kg/day | 3 - 5 mg/kg/day | Affects leydig cells function | Reproductive endocrine-mediated perturbations | |
| PMID:32084696 | IVR | 1 - 2 mg/kg/day | 1 - 2 mg/kg/day | Atrophy in seminiferous tubules | Reproductive endocrine-mediated perturbations |
| IVR | 1 - 2 mg/kg/day | 1 - 2 mg/kg/day | Changes in morphology of seminiferous tubules | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 2 mg/kg/day | 1 - 2 mg/kg/day | Decreased testosterone levels | Reproductive endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Affects intracellular signaling pathway | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg/day | 1 - 5 mg/kg/day | Epigenomic alterations in testis | Reproductive endocrine-mediated perturbations | |
| PMID:32328937 | IVR | 2 mg/kg | 2 mg/kg | Decreased testis weights | Reproductive endocrine-mediated perturbations |
| IVR | 2 mg/kg | 2 mg/kg | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| PMID:32503345 | IVR | 1 mg/kg | 1 mg/kg | Decreased body weights | Metabolic endocrine-mediated perturbations |
| IVR | 1 mg/kg | 1 mg/kg | Affects survival of live fetus | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased brain weights | Neurological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects thyroid function | Metabolic endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Affects social behavior | Neurological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Induce behavioral changes | Neurological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Altered cell cycle in neurons | Neurological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Cognitive impairment | Neurological endocrine-mediated perturbations | |
| PMID:33611912 | IVR | 1 mg/kg/day | 1 mg/kg/day | Affects neuronal function | Neurological endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Alteration in prostate morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Affects cell metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:34082246 | IVTH | 0.00001 M | 0.00001 M | Increased progesterone levels | Reproductive endocrine-mediated perturbations |
| IVTH | 0.00001 - 0.000025 M | 0.00001 - 0.000025 M | Affects steroidogenesis | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.0000025 - 0.00005 M | 0.0000025 - 0.00005 M | Affects glucose metabolism | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.00001 - 0.0001 M | 0.00001 - 0.0001 M | Decreased mitochondrial membrane potential in granulosa cells | Reproductive endocrine-mediated perturbations | |
| IVTH | 0.00001 M | 0.00001 M | Increased estradiol levels | Reproductive endocrine-mediated perturbations | |
| PMID:34166923 | IVR | 4 - 32 mg/kg/day | 4 - 32 mg/kg/day | Decreased weights of epididymis | Reproductive endocrine-mediated perturbations |
| IVR | 4 - 32 mg/kg/day | 4 - 32 mg/kg/day | Decreased weights of seminal vesicles | Reproductive endocrine-mediated perturbations | |
| IVR | 4 - 32 mg/kg/day | 4 - 32 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations | |
| IVR | 4 - 32 mg/kg/day | 4 - 32 mg/kg/day | Reduced sperm counts | Reproductive endocrine-mediated perturbations | |
| IVR | 4 - 32 mg/kg/day | 4 - 32 mg/kg/day | Increase in the number of abnormal sperms | Reproductive endocrine-mediated perturbations | |
| IVR | 4 - 32 mg/kg/day | 4 - 32 mg/kg/day | Changes in epididymal morphology | Reproductive endocrine-mediated perturbations | |
| IVR | 4 - 32 mg/kg/day | 4 - 32 mg/kg/day | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| PMID:34460931 | IVR | 3 mg/kg/day | 3 mg/kg/day | Affects liver function | Hepatic endocrine-mediated perturbations |
| IVR | 3 mg/kg/day | 3 mg/kg/day | Decrease in T3 levels | Metabolic endocrine-mediated perturbations | |
| IVR | 3 mg/kg/day | 3 mg/kg/day | Decrease in T4 levels | Metabolic endocrine-mediated perturbations | |
| PMID:34721297 | IVR | 2.4 mg/kg/day | 2.4 mg/kg/day | Affects sperm motility | Reproductive endocrine-mediated perturbations |
| IVR | 2.4 mg/kg/day | 2.4 mg/kg/day | Reduced sperm quality | Reproductive endocrine-mediated perturbations | |
| PMID:34736200 | IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects neuronal density | Neurological endocrine-mediated perturbations |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Changes in brain morphology | Neurological endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects social behavior | Neurological endocrine-mediated perturbations | |
| IVR | 1 mg/kg | 1 mg/kg | Decreased body weights | Metabolic endocrine-mediated perturbations | |
| IVR | 1 - 5 mg/kg | 1 - 5 mg/kg | Affects neuronal signaling | Neurological endocrine-mediated perturbations | |
| PMID:35970220 | IVR | 5 mg/kg/day | 5 mg/kg/day | Decreased progesterone levels | Reproductive endocrine-mediated perturbations |
| PMID:36182156 | IVR | 1 mg/kg/day | 1 mg/kg/day | Increased cholesterol levels | Metabolic endocrine-mediated perturbations |
| IVR | 1 mg/kg/day | 1 mg/kg/day | Increased triglycerides level | Metabolic endocrine-mediated perturbations | |
| PMID:36470526 | IVTH | 0.0001 M | 0.0001 M | Decreased progesterone levels | Reproductive endocrine-mediated perturbations |
| PMID:37431803 | IVTH | 0.000002 M | 0.000002 M | Affects carbohydrates metabolism | Metabolic endocrine-mediated perturbations |
| IVTH | 0.000002 M | 0.000002 M | Affects lipid metabolism | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.000002 M | 0.000002 M | Affects amino acid metabolism | Metabolic endocrine-mediated perturbations | |
| PMID:38048832 | IVTH | 0.00003 M | 0.00003 M | Reduced glucose levels | Metabolic endocrine-mediated perturbations |
| IVTH | 0.00003 M | 0.00003 M | Altered adipocyte morphology | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.00003 M | 0.00003 M | Increased leptin levels | Metabolic endocrine-mediated perturbations | |
| IVTH | 0.00003 M | 0.00003 M | Altered lipid composition in adipocytes | Metabolic endocrine-mediated perturbations |
We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.