Bisphenol AF


Curated chemical-phenotype interactions from CTD
GO IDGO nameInteraction typeReference
GO:0000084 Mitotic s phase Affects phenotype PMID:31059536; PMID:38211720
GO:0000085 Mitotic g2 phase Affects phenotype PMID:38211720
GO:0000278 Mitotic cell cycle Affects phenotype PMID:31059536
GO:0000737 Dna catabolic process, endonucleolytic Increases phenotype PMID:35395335
GO:0001541 Ovarian follicle development Affects phenotype PMID:36464114; PMID:39938710
GO:0001552 Ovarian follicle atresia Increases phenotype PMID:30675821
GO:0001553 Luteinization Decreases phenotype PMID:30675821
GO:0001649 Osteoblast differentiation Decreases phenotype PMID:34850234
GO:0001958 Endochondral ossification Decreases phenotype PMID:34850234
GO:0002062 Chondrocyte differentiation Decreases phenotype PMID:34850234
GO:0002176 Male germ cell proliferation Decreases phenotype PMID:37216864
GO:0002253 Activation of immune response Increases phenotype PMID:39151878
GO:0003300 Cardiac muscle hypertrophy Increases phenotype PMID:37611474
GO:0004457 Lactate dehydrogenase activity Increases phenotype PMID:33662508
GO:0004784 Superoxide dismutase activity Affects phenotype PMID:35395335; PMID:39059691
GO:0005757 Mitochondrial permeability transition pore complex Increases phenotype PMID:33662508
GO:0006089 Lactate metabolic process Affects phenotype PMID:37094511
GO:0006096 Glycolytic process Increases phenotype PMID:37094511
GO:0006171 Camp biosynthetic process Increases phenotype PMID:28858478; PMID:29575470
GO:0006304 Dna modification Increases phenotype PMID:36464114
GO:0006520 Amino acid metabolic process Affects phenotype PMID:37094511
GO:0006523 Alanine biosynthetic process Affects phenotype PMID:31121516
GO:0006537 Glutamate biosynthetic process Affects phenotype PMID:31121516
GO:0006542 Glutamine biosynthetic process Affects phenotype PMID:31121516
GO:0006545 Glycine biosynthetic process Affects phenotype PMID:31121516
GO:0006629 Lipid metabolic process Affects phenotype PMID:31596606; PMID:36632902
GO:0006631 Fatty acid metabolic process Affects phenotype PMID:36632902
GO:0006633 Fatty acid biosynthetic process Affects phenotype PMID:30145421
GO:0006641 Triglyceride metabolic process Affects phenotype PMID:36632902
GO:0006695 Cholesterol biosynthetic process Decreases phenotype PMID:30145421
GO:0006749 Glutathione metabolic process Affects phenotype PMID:28259788; PMID:37094511
GO:0006754 Atp biosynthetic process Decreases phenotype PMID:29079494
GO:0006874 Cellular calcium ion homeostasis Affects phenotype PMID:30590302; PMID:32508751; PMID:33662508; PMID:34748853
GO:0006974 Cellular response to dna damage stimulus Increases phenotype PMID:27633978; PMID:31207516; PMID:32244372; PMID:32244372
GO:0006997 Nucleus organization Affects phenotype PMID:36625514
GO:0007010 Cytoskeleton organization Affects phenotype PMID:27633978; PMID:36625514
GO:0007040 Lysosome organization Decreases phenotype PMID:33662508
GO:0007049 Cell cycle Affects phenotype PMID:27633978
GO:0007128 Meiotic prophase i Affects phenotype PMID:36464114
GO:0007283 Spermatogenesis Decreases phenotype PMID:36098747; PMID:37216864
GO:0007340 Acrosome reaction Increases phenotype PMID:32508751
GO:0007566 Embryo implantation Decreases phenotype PMID:38043716
GO:0008203 Cholesterol metabolic process Affects phenotype PMID:36632902
GO:0008206 Bile acid metabolic process Affects phenotype PMID:36632902
GO:0008210 Estrogen metabolic process Affects phenotype PMID:39938710
GO:0008219 Cell death Affects phenotype PMID:31059536; PMID:33662508; PMID:36625514
GO:0008283 Cell population proliferation Affects phenotype PMID:26435001; PMID:37094511; PMID:37182577; PMID:38003411
GO:0008284 Positive regulation of cell population proliferation Affects phenotype PMID:24349450; PMID:28591870; PMID:29093337; PMID:30099086
GO:0008285 Negative regulation of cell population proliferation Increases phenotype PMID:29555536; PMID:31981723; PMID:32763284; PMID:34174261; PMID:39059691
GO:0008380 Rna splicing Affects phenotype PMID:36464114
GO:0008584 Male gonad development Affects phenotype PMID:39938710
GO:0008610 Lipid biosynthetic process Increases phenotype PMID:30408883
GO:0008652 Amino acid biosynthetic process Affects phenotype PMID:31121516
GO:0009094 L-phenylalanine biosynthetic process Affects phenotype PMID:31121516
GO:0009099 Valine biosynthetic process Affects phenotype PMID:31121516
GO:0009437 Carnitine metabolic process Affects phenotype PMID:37094511
GO:0010613 Positive regulation of cardiac muscle hypertrophy Increases phenotype PMID:31981723
GO:0010825 Positive regulation of centrosome duplication Increases phenotype PMID:27998958
GO:0010940 Positive regulation of necrotic cell death Increases phenotype PMID:39059691
GO:0010972 Negative regulation of g2/m transition of mitotic cell cycle Increases phenotype PMID:35940389
GO:0016042 Lipid catabolic process Affects phenotype PMID:33662508; PMID:35605789
GO:0016525 Negative regulation of angiogenesis Increases phenotype PMID:38043716
GO:0016887 Atp hydrolysis activity Decreases phenotype PMID:29079494
GO:0018158 Protein oxidation Increases phenotype PMID:29079494
GO:0019413 Acetate biosynthetic process Affects phenotype PMID:31121516
GO:0019432 Triglyceride biosynthetic process Decreases phenotype PMID:30145421
GO:0019752 Carboxylic acid metabolic process Affects phenotype PMID:37094511
GO:0030041 Actin filament polymerization Decreases phenotype PMID:33662508
GO:0030168 Platelet activation Increases phenotype PMID:33662508
GO:0030263 Apoptotic chromosome condensation Increases phenotype PMID:37023647
GO:0030335 Positive regulation of cell migration Increases phenotype PMID:36190352
GO:0030879 Mammary gland development Increases phenotype PMID:30102602
GO:0031324 Negative regulation of cellular metabolic process Increases phenotype PMID:34174261
GO:0031914 Negative regulation of synaptic plasticity Increases phenotype PMID:34134381
GO:0032125 Micronucleus organization Increases phenotype PMID:35395335
GO:0032776 Dna methylation on cytosine Affects phenotype PMID:36464114
GO:0032869 Cellular response to insulin stimulus Affects phenotype PMID:34186270
GO:0033148 Positive regulation of intracellular estrogen receptor signaling pathway Increases phenotype PMID:27473340; PMID:29093337; PMID:31388671
GO:0033327 Leydig cell differentiation Decreases phenotype PMID:36098747; PMID:37216864
GO:0034440 Lipid oxidation Increases phenotype PMID:28259788; PMID:36632902
GO:0035037 Sperm entry Increases phenotype PMID:32508751
GO:0035176 Social behavior Decreases phenotype PMID:37023647
GO:0035641 Locomotory exploration behavior Decreases phenotype PMID:37023647
GO:0035847 Uterine epithelium development Increases phenotype PMID:27473340
GO:0035937 Estrogen secretion Affects phenotype PMID:37182577
GO:0040015 Negative regulation of multicellular organism growth Increases phenotype PMID:34134381
GO:0040018 Positive regulation of multicellular organism growth Decreases phenotype PMID:27567155
GO:0042403 Thyroid hormone metabolic process Affects phenotype PMID:36881955
GO:0042554 Superoxide anion generation Affects phenotype PMID:33662508
GO:0042701 Progesterone secretion Affects phenotype PMID:37182577
GO:0042816 Vitamin b6 metabolic process Affects phenotype PMID:37094511
GO:0042866 Pyruvate biosynthetic process Affects phenotype PMID:31121516
GO:0043065 Positive regulation of apoptotic process Increases phenotype PMID:35940389
GO:0043648 Dicarboxylic acid metabolic process Affects phenotype PMID:37094511
GO:0043929 Primary ovarian follicle growth involved in double layer follicle stage Decreases phenotype PMID:30675821
GO:0044237 Cellular metabolic process Increases phenotype PMID:30590302; PMID:31059536; PMID:31812737; PMID:32244372; PMID:33662508; PMID:34748853; PMID:37182577; PMID:37715983; PMID:38211720
GO:0044319 Wound healing, spreading of cells Increases phenotype PMID:28858478; PMID:31059536
GO:0045023 G0 to g1 transition Affects phenotype PMID:31059536; PMID:38211720
GO:0045066 Regulatory t cell differentiation Affects phenotype PMID:37023647
GO:0045333 Cellular respiration Affects phenotype PMID:31596606; PMID:37094511
GO:0045429 Positive regulation of nitric oxide biosynthetic process Increases phenotype PMID:31981723
GO:0045444 Fat cell differentiation Affects phenotype PMID:34186270
GO:0045454 Cell redox homeostasis Decreases phenotype PMID:34134381
GO:0045833 Negative regulation of lipid metabolic process Increases phenotype PMID:39151878
GO:0046031 Adp metabolic process Affects phenotype PMID:37094511
GO:0046083 Adenine metabolic process Affects phenotype PMID:37094511
GO:0046110 Xanthine metabolic process Affects phenotype PMID:37094511
GO:0046621 Negative regulation of organ growth Increases phenotype PMID:30675821
GO:0046622 Positive regulation of organ growth Increases phenotype PMID:27473340
GO:0048477 Oogenesis Affects phenotype PMID:36464114
GO:0048666 Neuron development Decreases phenotype PMID:37023647
GO:0051309 Female meiosis chromosome separation Affects phenotype PMID:36464114
GO:0051321 Meiotic cell cycle Affects phenotype PMID:36464114
GO:0051332 Meiotic s phase Affects phenotype PMID:36464114
GO:0051726 Regulation of cell cycle Increases phenotype PMID:31750923
GO:0051881 Regulation of mitochondrial membrane potential Affects phenotype PMID:37094511
GO:0055074 Calcium ion homeostasis Affects phenotype PMID:28858478
GO:0060009 Sertoli cell development Decreases phenotype PMID:37216864
GO:0061370 Testosterone biosynthetic process Increases phenotype PMID:27567155; PMID:35605789; PMID:36098747; PMID:37216864; PMID:39938710
GO:0070059 Intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress Increases phenotype PMID:35940389
GO:0070266 Necroptotic process Increases phenotype PMID:33662508
GO:0070994 Detection of oxidative stress Increases phenotype PMID:35940389
GO:0071466 Cellular response to xenobiotic stimulus Affects phenotype PMID:30145421
GO:0072520 Seminiferous tubule development Decreases phenotype PMID:36098747; PMID:37216864
GO:0072593 Reactive oxygen species metabolic process Affects phenotype PMID:33662508; PMID:34748853; PMID:34748853; PMID:38211720; PMID:38211720
GO:0097045 Phosphatidylserine exposure on blood platelet Increases phenotype PMID:33662508
GO:0097722 Sperm motility Increases phenotype PMID:32508751
GO:0099563 Modification of synaptic structure Increases phenotype PMID:37023647
GO:0110053 Regulation of actin filament organization Affects phenotype PMID:31750923
GO:0140013 Meiotic nuclear division Affects phenotype PMID:35605789
GO:0140042 Lipid droplet formation Increases phenotype PMID:32763284
GO:0140059 Dendrite arborization Decreases phenotype PMID:34134381
GO:1901670 Negative regulation of superoxide dismutase activity Increases phenotype PMID:38043716
GO:1901671 Positive regulation of superoxide dismutase activity Decreases phenotype PMID:28259788
GO:1901726 Negative regulation of histone deacetylase activity Increases phenotype PMID:36534918
GO:1902110 Positive regulation of mitochondrial membrane permeability involved in apoptotic process Increases phenotype PMID:35940389
GO:1902884 Positive regulation of response to oxidative stress Increases phenotype PMID:39151878
GO:1902951 Negative regulation of dendritic spine maintenance Increases phenotype PMID:34134381
GO:1903046 Meiotic cell cycle process Affects phenotype PMID:36464114
GO:1903047 Mitotic cell cycle process Affects phenotype PMID:38211720
GO:1903353 Regulation of nucleus organization Affects phenotype PMID:31750923
GO:1903409 Reactive oxygen species biosynthetic process Increases phenotype PMID:30590302
GO:1903428 Positive regulation of reactive oxygen species biosynthetic process Increases phenotype PMID:28259788; PMID:34174261; PMID:39059691
GO:1903709 Uterine gland development Increases phenotype PMID:27473340; PMID:36881955
GO:1903966 Monounsaturated fatty acid biosynthetic process Affects phenotype PMID:30145421
GO:1990138 Neuron projection extension Decreases phenotype PMID:31812737
GO:2000184 Positive regulation of progesterone biosynthetic process Increases phenotype PMID:29575470
GO:2000278 Regulation of dna biosynthetic process Affects phenotype PMID:31750923
GO:2000845 Positive regulation of testosterone secretion Increases phenotype PMID:27567155
GO:2000865 Negative regulation of estradiol secretion Increases phenotype PMID:38043716
GO:2000871 Negative regulation of progesterone secretion Increases phenotype PMID:30675821; PMID:38043716
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.