Bisphenol AF

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:17904329	IVR	1000 mg/kg/day	1000 mg/kg/day	Uterotrophic effect	Reproductive endocrine-mediated perturbations
PMID:21713527	IVR	100 mg/kg/day	100 mg/kg/day	Changes in haemocrit values	Immunological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Atrophy of mammary gland	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Increase in T4 levels	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased weights of accessory sex organs	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Changes in adrenal gland morphology	Metabolic endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Changes in white blood cell (WBC) populations	Immunological endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	-	No significant effects observed	-
	IVR	30 mg/kg/day	30 mg/kg/day	Abnormal estrous cycles	Reproductive endocrine-mediated perturbations
PMID:22504055	IVR	200 mg/kg/day	200 mg/kg/day	Affects the normal functioning of reproductive system	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Increased testis weights	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects cholesterol metabolism	Metabolic endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	200 mg/kg/day	200 mg/kg/day	Affects steroid metabolism	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	-	No significant effects observed	-
	IVR	50 mg/kg/day	50 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVR	50 mg/kg/day	50 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	10 mg/kg/day	10 mg/kg/day	Increased FSH levels	Reproductive endocrine-mediated perturbations
PMID:26435001	IVTH	0.000000001 - 0.00001 M	0.0000001 - 0.00001 M	Cancer phenotype	Endocrine-mediated cancer
PMID:26751127	IVTH	0.00001 - 0.0005 M	0.000001 - 0.00007 M	Decreased progestagens levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0005 M	0.000001 - 0.00007 M	Decreased aldosterone levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00001 - 0.0005 M	0.000001 - 0.00007 M	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.00001 - 0.0005 M	0.000001 - 0.00007 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:27567155	IVR	100 mg/kg/day	100 mg/kg/day	Increased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Affects sexual behavior	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	100 mg/kg/day	100 mg/kg/day	Decreased inhibin-B levels	Reproductive endocrine-mediated perturbations
PMID:28735473	IVTH	0.0000001 M	0.0000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00000001 M	0.00000001 M	Increased calcium levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.0000001 M	0.0000001 M	Increased calcium levels	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Increased calcium levels	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00001 M	0.00001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.00001 M	0.00001 M	Increased calcium levels	Metabolic endocrine-mediated perturbations
PMID:30102602	IVR	0.05 mg/kg	0.05 mg/kg	Alters mammary gland development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.05 mg/kg	0.05 mg/kg	Changes in mammary gland morphology in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg	0.5 mg/kg	Alters mammary gland development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.5 mg/kg	0.5 mg/kg	Changes in mammary gland morphology in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Alters mammary gland development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Changes in mammary gland morphology in offspring	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:30613871	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Affects cell metabolism	Metabolic endocrine-mediated perturbations
PMID:30823348	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Increased hepatic glycogen levels in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Oxidative stress in liver in offspring	Developmental endocrine-mediated perturbations;Hepatic endocrine-mediated perturbations
PMID:31059536	IVTH	0.0000001 M	0.0000001 M	Induce tumor progression	Endocrine-mediated cancer
	IVTH	0.0000001 M	0.0000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.000001 M	0.000001 M	Induced migration capability of tumor cells	Endocrine-mediated cancer
	IVTH	0.000001 M	0.000001 M	Induce tumor progression	Endocrine-mediated cancer
	IVTH	0.000001 M	0.000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.0000005 M	0.0000005 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.000005 M	0.000005 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.0000005 M	0.0000005 M	Induce tumor progression	Endocrine-mediated cancer
	IVTH	0.000005 M	0.000005 M	Induce tumor progression	Endocrine-mediated cancer
PMID:31362132	IVR	5 mg/kg	5 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg	5 mg/kg	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	20 mg/kg	20 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Oxidative stress in sperm	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Affects fertility	Reproductive endocrine-mediated perturbations
	IVR	50 mg/kg	50 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
PMID:31388671	IVTH	0.000001 M	0.000001 M	Cancer phenotype	Endocrine-mediated cancer
	IVTH	0.000001 M	0.000001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
PMID:31596606	IVTH	0.000000005 M	0.000000005 M	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVTH	0.000000005 M	0.000000005 M	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVTH	0.000000005 M	0.000000005 M	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVTH	0.000005 M	-	No significant effects observed	-
	IVTH	0.00000005 M	-	No significant effects observed	-
PMID:32289607	IVTH	0.0000001 - 0.0001 M	0.0000001 - 0.0001 M	Oxidative stress in granulosa cells	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Increased calcium levels	Metabolic endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Decreased mitochondrial membrane potential in granulosa cells	Reproductive endocrine-mediated perturbations
PMID:32508751	IVTH	0.000025 M	0.0000024 M	Affects calcium signaling in sperm	Reproductive endocrine-mediated perturbations
PMID:33866271	IVTH	0.0000000003 - 0.0000003 M	0.0000000003 - 0.0000003 M	Induce apoptosis in mesenchymal stem cells	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVTH	0.000000003 - 0.0000003 M	0.000000003 - 0.0000003 M	Changes in morphology of mesenchymal stem cells	Metabolic endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
PMID:33885253	IVTH	0.00001 M	0.00001 M	Affects granulosa cells function	Reproductive endocrine-mediated perturbations
PMID:34069744	IVTH	0.00001 M	0.00001 M	Induce apotosis in adipocytes	Metabolic endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00001 M	0.0000001 - 0.00001 M	Altered adipogenesis	Metabolic endocrine-mediated perturbations
PMID:34134381	IVR	0.34 - 34 mg/kg/day	0.34 - 34 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	0.34 - 34 mg/kg/day	0.34 - 34 mg/kg/day	Affects expression of estrogen receptor-beta (ER-beta)	Reproductive endocrine-mediated perturbations
	IVR	0.034 - 34 mg/kg/day	0.034 - 34 mg/kg/day	Oxidative stress in neurons	Neurological endocrine-mediated perturbations
	IVR	3.4 - 34 mg/kg/day	3.4 - 34 mg/kg/day	Affects neuronal density	Neurological endocrine-mediated perturbations
	IVR	0.034 - 34 mg/kg/day	0.034 - 34 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	3.4 mg/kg/day	3.4 mg/kg/day	Decreased body weights	Metabolic endocrine-mediated perturbations
	IVR	0.034 - 34 mg/kg/day	0.034 - 34 mg/kg/day	Changes in brain morphology	Neurological endocrine-mediated perturbations
	IVR	0.34 - 34 mg/kg/day	0.34 - 34 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
PMID:34141841	IVTH	0.00000003 M	0.0000000012 M	Induce apoptosis in adipose tissue	Metabolic endocrine-mediated perturbations
PMID:34174261	IVTH	0.00001 M	0.00001 M	Causes inflammation	Immunological endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Oxidative stress in granulosa cells	Reproductive endocrine-mediated perturbations
PMID:34186270	IVTH	0.00000001 - 0.00005 M	0.00000001 - 0.00005 M	Affects lipid metabolism	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVTH	0.00000001 M	0.00000001 M	Increased leptin levels	Metabolic endocrine-mediated perturbations
	IVTH	0.000001 M	0.000001 M	Decreased adiponectin levels	Metabolic endocrine-mediated perturbations
PMID:35026324	IVR	1 - 2 mg/kg	1 - 2 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased pregnenolone levels	Reproductive endocrine-mediated perturbations
	IVR	1 - 2 mg/kg	1 - 2 mg/kg	Induce autophagy in testis	Reproductive endocrine-mediated perturbations
	IVR	1 mg/kg	1 mg/kg	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased estriol levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	1 - 2 mg/kg	1 - 2 mg/kg	Decreased body weights	Metabolic endocrine-mediated perturbations
	IVR	1 - 2 mg/kg	1 - 2 mg/kg	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	1 - 2 mg/kg	1 - 2 mg/kg	Decreased testis weights	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased weights of epididymis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	1 - 2 mg/kg	1 - 2 mg/kg	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	1 - 2 mg/kg	1 - 2 mg/kg	Induce apoptosis in testis	Reproductive endocrine-mediated perturbations
	IVR	1 - 2 mg/kg	1 - 2 mg/kg	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	1 - 2 mg/kg	1 - 2 mg/kg	Induce apoptosis in seminiferous tubules	Reproductive endocrine-mediated perturbations
PMID:35101577	IVTH	0.0001 M	0.0001 M	Reduced adiposity	Metabolic endocrine-mediated perturbations
	IVTH	0.00003 M	0.00003 M	Altered adipocyte morphology	Metabolic endocrine-mediated perturbations
PMID:35183564	IVR	0.4 - 4 mg/kg/day	0.4 - 4 mg/kg/day	Decreased body weights in offspring	Developmental endocrine-mediated perturbations;Metabolic endocrine-mediated perturbations
	IVR	0.4 - 4 mg/kg/day	0.4 - 4 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
PMID:35605789	IVR	2 - 5 mg/kg/day	2 - 5 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg/day	2 mg/kg/day	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	2 - 5 mg/kg/day	2 - 5 mg/kg/day	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
	IVR	2 - 5 mg/kg/day	2 - 5 mg/kg/day	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	2 - 5 mg/kg/day	2 - 5 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:35940389	IVTH	0.00001 M	0.00001 M	Altered cell cycle of endometrial cells	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 M	0.00001 M	Induce apoptosis of endometrial cells	Reproductive endocrine-mediated perturbations
PMID:36098747	IVR	5 mg/kg/day	5 mg/kg/day	Abnormal proliferation of germ cells	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/kg/day	0.05 - 5 mg/kg/day	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/kg/day	0.05 - 5 mg/kg/day	Affects testicular development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.15 - 5 mg/L	0.15 - 5 mg/L	Affects leydig cells function	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/L	0.05 - 5 mg/L	Affects testicular development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Alterations in number of leydig cells	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased gonadotropin-releasing hormone (GnRH) levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/kg/day	0.05 - 5 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/L	0.05 - 5 mg/L	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/kg/day	0.05 - 5 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	0.15 mg/L	0.15 mg/L	Decreased liver weights	Hepatic endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Increased liver weights	Hepatic endocrine-mediated perturbations
	IVR	0.15 - 5 mg/L	0.15 - 5 mg/L	Decreased body weights	Metabolic endocrine-mediated perturbations
	IVR	0.15 - 5 mg/kg/day	0.15 - 5 mg/kg/day	Decreased body weights	Metabolic endocrine-mediated perturbations
	IVR	0.15 - 5 mg/kg/day	0.15 - 5 mg/kg/day	Affects leydig cells function	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Decreased FSH levels	Reproductive endocrine-mediated perturbations
	IVR	0.05 - 5 mg/kg/day	0.05 - 5 mg/kg/day	Decreased LH levels	Reproductive endocrine-mediated perturbations
	IVR	5 mg/kg/day	5 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:36293141	IVR	0.09 mg/kg	0.09 mg/kg	Alteration in prostate morphology	Reproductive endocrine-mediated perturbations
	IVR	0.09 mg/kg	0.09 mg/kg	Increased prostate weights	Reproductive endocrine-mediated perturbations
	IVR	0.00000001 - 0.09 mg/kg	0.00000001 - 0.09 mg/kg	Causes inflammation	Immunological endocrine-mediated perturbations
	IVTH	0.00000001 - 0.09 M	0.00000001 - 0.09 M	Causes inflammation	Immunological endocrine-mediated perturbations
PMID:37216864	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Causes inflammation	Immunological endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Reduced sperm quality	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Decreased weights of seminal vesicles	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Induce immunological response in testis	Immunological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Changes in T-cell populations	Immunological endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Changes in morphology of seminiferous tubules	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg/day	0.3 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:37237912	IVR	5 mg/kg/day	5 mg/kg/day	Reduced sperm quality	Reproductive endocrine-mediated perturbations
PMID:37586593	IVR	2 mg/kg	2 mg/kg	Increase in the number of abnormal sperms	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Causes inflammation	Immunological endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Changes in testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Induce apoptosis in testis	Reproductive endocrine-mediated perturbations
PMID:37715983	IVTH	0.0001 M	0.0001 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
PMID:37939739	IVTH	0.000001 - 0.0001 M	0.000001 - 0.0001 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:38043716	IVR	3 mg/kg/day	3 mg/kg/day	Affects embryonic development	Developmental endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased ovarian weights	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects ovarian angiogenesis	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Causes inflammation	Immunological endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Oxidative stress in ovaries	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects expression of estrogen receptor-alpha (ER-alpha)	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects ovarian follicles population	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	3 mg/kg/day	3 mg/kg/day	Changes in ovarian morphology	Reproductive endocrine-mediated perturbations
PMID:38276253	IVTH	0.0001 M	0.0001 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000001 - 0.000075 M	0.000001 - 0.000075 M	Decreased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVTH	0.0000001 - 0.0001 M	0.0000001 - 0.0001 M	Increased cholesterol levels	Metabolic endocrine-mediated perturbations
	IVTH	0.00000005 - 0.00005 M	0.00000005 - 0.00005 M	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00000005 - 0.0000001 M	0.00000005 - 0.0000001 M	Increase in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.000001 - 0.0001 M	0.000001 - 0.0001 M	Decrease in cortisol levels	Neurological endocrine-mediated perturbations
	IVTH	0.00000005 - 0.0001 M	0.00000005 - 0.0001 M	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00005 - 0.0001 M	0.00005 - 0.0001 M	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.0000001 - 0.00001 M	0.0000001 - 0.00001 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
PMID:38702036	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Induce apoptosis of granulosa cells	Reproductive endocrine-mediated perturbations
	IVTH	0.00001 - 0.0001 M	0.00001 - 0.0001 M	Induce mitochondrial dysfunction in granulosa cells	Reproductive endocrine-mediated perturbations
	IVTH	0.0001 M	0.0001 M	Oxidative stress in granulosa cells	Reproductive endocrine-mediated perturbations
PMID:38997027	IVTH	0.000001 - 0.00005 M	0.000001 - 0.00005 M	Affects intracellular signaling pathway	Metabolic endocrine-mediated perturbations
PMID:39160422	IVR	2 mg/kg	2 mg/kg	Increase in the number of abnormal sperms	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Induce apoptosis in testis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Reduced sperm counts	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects sperm motility	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Oxidative stress in testis	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Affects testicular morphology	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	2 mg/kg	2 mg/kg	Causes inflammation	Immunological endocrine-mediated perturbations
PMID:39520287	IVTH	0.000005 - 0.00002 M	0.000005 - 0.00002 M	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 - 0.00002 M	0.000005 - 0.00002 M	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVTH	0.000005 - 0.00002 M	0.000005 - 0.00002 M	Increased estradiol levels	Reproductive endocrine-mediated perturbations
PMID:39549911	IVR	0.3 mg/kg	0.3 mg/kg	Changes in mammary gland morphology	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Decreased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Alters mammary gland development	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Increased progesterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Accelerated onset of puberty	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Alterations in vaginal opening	Reproductive endocrine-mediated perturbations
	IVR	0.3 mg/kg	0.3 mg/kg	Hyperplasia in mammary glands	Reproductive endocrine-mediated perturbations
PMID:9449681	IVTH	0.0000000001 - 0.00000001 M	0.0000000001 - 0.00000001 M	Affects expression of progesterone receptor (PR)	Reproductive endocrine-mediated perturbations
	IVTH	0.0000000001 - 0.00000001 M	0.0000000001 - 0.00000001 M	Occurrence of mammary gland tumor	Endocrine-mediated cancer;Reproductive endocrine-mediated perturbations

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DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.