Bisphenol AF


ToxCast endpoints for intended target type: RNA
Assay NameTissueOrganismTarget Gene IDTarget HGNC SymbolResponseAC50 Value
LTEA_HepaRG_CCND2LiverHuman894CCND2Inhibitory0.15 μM

ToxCast endpoints for intended target type: Protein
Assay NameTissueOrganismTarget Gene IDTarget HGNC SymbolResponseAC50 Value
CCTE_GLTED_hTTR_0.125uMHuman7276TTRLoss2.22 μM
ATG_AP_1_CISLiverHuman2353|3725FOS|JUNInhibitory5.43 μM
ATG_DR4_LXR_CISLiverHuman7376|10062NR1H2|NR1H3Activatory8.79 μM
ATG_ERE_CISLiverHuman2099ESR1Inhibitory0.09 μM
ATG_IR1_CISLiverHuman9971NR1H4Activatory9.95 μM
ATG_ISRE_CISLiverHuman3659IRF1Activatory11.1 μM
ATG_NRF2_ARE_CISLiverHuman4780NFE2L2Inhibitory11.1 μM
ATG_PXRE_CISLiverHuman8856NR1I2Activatory2.73 μM
ATG_TCF_b_cat_CISLiverHuman6932|6934|51176|83439TCF7|TCF7L2|LEF1|TCF7L1Activatory11.1 μM
ATG_VDRE_CISLiverHuman7421VDRInhibitory14.92 μM
ATG_ERa_TRANSLiverHuman2099ESR1Gain0.09 μM
ATG_PXR_TRANSLiverHuman8856NR1I2Gain6.16 μM
ATG_RXRb_TRANSLiverHuman6257RXRBGain3.18 μM
ATG_Ahr_CISLiverHuman196AHRInhibitory13.31 μM
ATG_AP_1_CISLiverHuman2353|3725FOS|JUNInhibitory13.09 μM
ATG_DR4_LXR_CISLiverHuman7376|10062NR1H2|NR1H3Activatory12.85 μM
ATG_EGR_CISLiverHuman1958EGR1Activatory11.1 μM
ATG_ERE_CISLiverHuman2099ESR1Activatory0.2 μM
ATG_MRE_CISLiverHuman4520MTF1Inhibitory14.91 μM
ATG_NRF2_ARE_CISLiverHuman4780NFE2L2Inhibitory9.55 μM
ATG_PXRE_CISLiverHuman8856NR1I2Inhibitory5.27 μM
ATG_VDRE_CISLiverHuman7421VDRActivatory12.67 μM
ATG_ERa_TRANSLiverHuman2099ESR1Gain0.18 μM
ATG_PXR_TRANSLiverHuman8856NR1I2Gain5.91 μM
ATG_RXRb_TRANSLiverHuman6257RXRBGain5.39 μM
ATG_Ahr_CISLiverHuman196AHRActivatory5.94 μM
ATG_AP_1_CISLiverHuman2353|3725FOS|JUNInhibitory6.82 μM
ATG_ERE_CISLiverHuman2099ESR1Inhibitory0.11 μM
ATG_HSE_CISLiverHuman3297HSF1Inhibitory15.46 μM
ATG_MRE_CISLiverHuman4520MTF1Inhibitory13.34 μM
ATG_NRF2_ARE_CISLiverHuman4780NFE2L2Inhibitory7.55 μM
ATG_Pax6_CISLiverHuman5080PAX6Inhibitory8.18 μM
ATG_PPRE_CISLiverHuman5465|5467|5468PPARA|PPARD|PPARGInhibitory5.74 μM
ATG_PXRE_CISLiverHuman8856NR1I2Inhibitory3.74 μM
ATG_TCF_b_cat_CISLiverHuman6932|6934|51176|83439TCF7|TCF7L2|LEF1|TCF7L1Inhibitory8.78 μM
ATG_VDRE_CISLiverHuman7421VDRInhibitory11.1 μM
ATG_ERa_TRANSLiverHuman2099ESR1Gain0.13 μM
ATG_NURR1_TRANSLiverHuman4929NR4A2Gain11.1 μM
ATG_PXR_TRANSLiverHuman8856NR1I2Gain4.89 μM
ATG_RXRb_TRANSLiverHuman6257RXRBGain4.24 μM
NVS_NR_hERHuman2099ESR1Loss0.11 μM
NVS_NR_hGRHuman2908NR3C1Loss0.72 μM
NVS_NR_hPPARaHuman5465PPARALoss15.19 μM
NVS_NR_mERaMouse13982Esr1Loss0.01 μM
NVS_NR_rARProstateRat24208ArLoss4.51 μM
NVS_MP_rPBRKidneyRat24230TspoLoss7.15 μM
NVS_NR_hERHuman2099ESR1Loss0.04 μM
NVS_NR_hGRHuman2908NR3C1Loss0.33 μM
NVS_NR_rARProstateRat24208ArLoss1.57 μM
NVS_NR_hERHuman2099ESR1Loss0.02 μM
NVS_NR_hGRHuman2908NR3C1Loss0.36 μM
NVS_NR_mERaMouse13982Esr1Loss0.02 μM
NVS_NR_rARProstateRat24208ArLoss2.65 μM
ATG_Ahr_CISLiverHuman196AHRActivatory11.1 μM
ATG_AP_1_CISLiverHuman2353|3725FOS|JUNInhibitory11.1 μM
ATG_CRE_CISLiverHuman10488CREB3Activatory11.1 μM
ATG_DR4_LXR_CISLiverHuman7376|10062NR1H2|NR1H3Inhibitory11.1 μM
ATG_DR5_RAR_CISLiverHuman5914|5915|5916RARA|RARB|RARGInhibitory11.1 μM
ATG_ERE_CISLiverHuman2099ESR1Activatory0.13 μM
ATG_Ets_CISLiverHuman2113ETS1Activatory15.47 μM
ATG_NRF2_ARE_CISLiverHuman4780NFE2L2Inhibitory13.92 μM
ATG_PPRE_CISLiverHuman5465|5467|5468PPARA|PPARD|PPARGActivatory11.1 μM
ATG_PXRE_CISLiverHuman8856NR1I2Inhibitory4.17 μM
ATG_VDRE_CISLiverHuman7421VDRActivatory13.09 μM
ATG_ERa_TRANSLiverHuman2099ESR1Gain0.25 μM
ATG_PXR_TRANSLiverHuman8856NR1I2Gain5.98 μM
ATG_RXRb_TRANSLiverHuman6257RXRBGain4.99 μM
BSK_4H_MCP1VascularHuman6347CCL2Inhibitory12.45 μM
BSK_4H_VEGFRIIVascularHuman3791KDRInhibitory6.04 μM
BSK_CASM3C_IL8VascularHuman3576CXCL8Inhibitory6.39 μM
BSK_hDFCGF_CollagenIIISkinHuman1281COL3A1Inhibitory10.59 μM
BSK_hDFCGF_MCSFSkinHuman1435CSF1Inhibitory14.79 μM
BSK_hDFCGF_PAI1SkinHuman5054SERPINE1Inhibitory12.83 μM
BSK_hDFCGF_VCAM1SkinHuman7412VCAM1Inhibitory8.19 μM
NVS_ADME_hCYP19A1Human1588CYP19A1Loss5.78 μM
NVS_ADME_hCYP2B6Human1555CYP2B6Loss4.36 μM
NVS_ADME_hCYP2C19Human1557CYP2C19Loss0.14 μM
NVS_ADME_hCYP2C9Human1559CYP2C9Loss0.4 μM
NVS_ADME_hCYP3A4Human1576CYP3A4Loss7.6 μM
NVS_ADME_hCYP4F12Human66002CYP4F12Loss3.03 μM
NVS_ENZ_hAMPKa1Human5562PRKAA1Loss13.51 μM
NVS_ENZ_hMMP1Human4312MMP1Loss3.66 μM
NVS_GPCR_g5HT4BrainGuinea pig100135548Htr4Loss11.68 μM
NVS_GPCR_gLTB4SpleenGuinea pig100379538Ltb4rLoss0.44 μM
NVS_GPCR_gOpiateKBrainGuinea pig100135587Oprk1Loss14.05 μM
NVS_GPCR_h5HT2ABrainHuman3356HTR2ALoss7.43 μM
NVS_GPCR_h5HT6Human3362HTR6Loss0.35 μM
NVS_GPCR_hAdra2CHuman152ADRA2CLoss9.87 μM
NVS_GPCR_hAdrb1Human153ADRB1Loss15.03 μM
NVS_GPCR_hDRD1Human1812DRD1Loss2.7 μM
NVS_GPCR_hOpiate_muHuman4988OPRM1Loss3.6 μM
NVS_IC_rNaCh_site2BrainRat81574Scn1aLoss5.87 μM
NVS_LGIC_rGluNMDA_AgonistBrainRat24408Grin1Gain15.09 μM
NVS_NR_hARHuman367ARLoss3.09 μM
NVS_NR_hGRHuman2908NR3C1Loss0.71 μM
NVS_NR_hPRHuman5241PGRLoss1.32 μM
NVS_NR_mERaMouse13982Esr1Loss0.07 μM
NVS_NR_rARProstateRat24208ArLoss4.93 μM
NVS_NR_rMRBrainRat25672Nr3c2Loss13.95 μM
NVS_TR_gDATBrainGuinea pig100714898Slc6a3Loss11.59 μM
NVS_TR_hNETHuman6530SLC6A2Loss13.57 μM
NVS_GPCR_gMPeripheral_NonSelectiveBladderGuinea pig100379235Chrm3Loss13.58 μM
NVS_GPCR_h5HT5AHuman3361HTR5ALoss10.39 μM
NVS_GPCR_h5HT7Human3363HTR7Loss5.71 μM
NVS_GPCR_hDRD2sHuman1813DRD2Loss7.58 μM
NVS_GPCR_hDRD4.4Human1815DRD4Loss14.07 μM
NVS_GPCR_hOpiate_D1Human4985OPRD1Loss10.5 μM
NVS_NR_hCAR_AntagonistHuman9970NR1I3Loss0.0 μM
NVS_NR_hERHuman2099ESR1Loss0.15 μM
NVS_TR_rVMAT2BrainRat25549Slc18a2Loss10.11 μM
ATG_hERa_XSP1LiverHuman2099ESR1Gain0.04 μM
ATG_hERb_XSP1LiverHuman2100ESR2Gain0.01 μM
ATG_hERa_XSP1LiverHuman2099ESR1Gain0.13 μM
ATG_hERb_XSP1LiverHuman2100ESR2Gain0.08 μM
ATG_hERa_XSP2LiverHuman2099ESR1Gain0.41 μM
ATG_hERb_XSP2LiverHuman2100ESR2Gain0.06 μM
TOX21_ERa_BLA_Agonist_ratioKidneyHuman2099ESR1Gain0.45 μM
TOX21_ERa_LUC_VM7_AgonistBreastHuman2099ESR1Gain0.06 μM
TOX21_GR_BLA_Antagonist_ratioCervixHuman2908NR3C1Loss10.38 μM
TOX21_TR_LUC_GH3_AntagonistPituitary glandRat7067|7068THRA|THRBLoss13.2 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881BreastHuman367ARLoss14.69 μM
TOX21_CAR_LUC_AgonistLiverHuman9970NR1I3Gain10.63 μM
TOX21_CAR_LUC_AntagonistLiverHuman9970NR1I3Loss0.72 μM
TOX21_ERb_BLA_Antagonist_ratioKidneyHuman2100ESR2Loss0.37 μM
TOX21_PR_BLA_Antagonist_ratioKidneyHuman5241PGRLoss10.74 μM
TOX21_ERa_LUC_VM7_Agonist_10nM_ICI182780BreastHuman2099ESR1Gain3.12 μM
TOX21_p450_CYP2C19_AntagonistHuman1557CYP2C19Loss4.18 μM
TOX21_p450_CYP2C9_AntagonistHuman1559CYP2C9Loss2.71 μM
TOX21_ERa_BLA_Agonist_ratioKidneyHuman2099ESR1Gain1.07 μM
TOX21_ERa_LUC_VM7_AgonistBreastHuman2099ESR1Gain0.19 μM
TOX21_GR_BLA_Antagonist_ratioCervixHuman2908NR3C1Loss11.43 μM
TOX21_AR_LUC_MDAKB2_Antagonist_0.5nM_R1881BreastHuman367ARLoss12.61 μM
TOX21_AP1_BLA_Agonist_ratioCervixHuman2353|3725FOS|JUNGain14.37 μM
TOX21_CAR_LUC_AgonistLiverHuman9970NR1I3Gain6.88 μM
TOX21_CAR_LUC_AntagonistLiverHuman9970NR1I3Loss1.38 μM
TOX21_ERb_BLA_Antagonist_ratioKidneyHuman2100ESR2Loss0.33 μM
TOX21_PR_BLA_Antagonist_ratioKidneyHuman5241PGRLoss11.14 μM
TOX21_ERa_LUC_VM7_Agonist_10nM_ICI182780BreastHuman2099ESR1Gain5.66 μM
TOX21_p450_CYP2C19_AntagonistHuman1557CYP2C19Loss4.84 μM
TOX21_p450_CYP2C9_AntagonistHuman1559CYP2C9Loss2.72 μM

No ToxCast endpoints for intended target type: Molecular messenger

ToxCast endpoints for intended target type: Pathway
Assay NameTissueOrganismTarget Gene IDTarget HGNC SymbolResponseAC50 Value
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_AntagonistBoneHuman367ARLoss8.39 μM
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_Cytoplasm_Ratio_AntagonistBoneHuman367ARLoss5.86 μM
ACEA_ER_80hrBreastHuman2099ESR1Gain0.26 μM
ACEA_ER_80hrBreastHuman2099ESR1Gain0.19 μM
ACEA_ER_80hrBreastHuman2099ESR1Gain0.1 μM
OT_ER_ERaERa_0480KidneyHuman2099ESR1Gain1.13 μM
OT_ER_ERaERa_1440KidneyHuman2099ESR1Gain1.13 μM
OT_ER_ERaERb_0480KidneyHuman2099|2100ESR1|ESR2Gain0.18 μM
OT_ER_ERaERb_1440KidneyHuman2099|2100ESR1|ESR2Gain0.78 μM
OT_ER_ERbERb_0480KidneyHuman2100ESR2Gain0.01 μM
OT_ER_ERbERb_1440KidneyHuman2100ESR2Gain0.01 μM
OT_ERa_GFPERaERE_0120CervixHuman2099ESR1Gain0.17 μM
OT_ERa_GFPERaERE_0480CervixHuman2099ESR1Gain0.21 μM
OT_FXR_FXRSRC1_0480KidneyHuman6714|9971SRC|NR1H4Gain12.63 μM
OT_FXR_FXRSRC1_1440KidneyHuman6714|9971SRC|NR1H4Gain12.77 μM
OT_ER_ERaERa_0480KidneyHuman2099ESR1Gain1.02 μM
OT_ER_ERaERa_1440KidneyHuman2099ESR1Gain0.86 μM
OT_ER_ERaERb_0480KidneyHuman2099|2100ESR1|ESR2Gain0.16 μM
OT_ER_ERaERb_1440KidneyHuman2099|2100ESR1|ESR2Gain1.01 μM
OT_ER_ERbERb_0480KidneyHuman2100ESR2Gain0.02 μM
OT_ERa_GFPERaERE_0120CervixHuman2099ESR1Gain0.03 μM
OT_ERa_GFPERaERE_0480CervixHuman2099ESR1Gain0.19 μM
OT_FXR_FXRSRC1_1440KidneyHuman6714|9971SRC|NR1H4Gain12.98 μM
OT_ER_ERaERa_0480KidneyHuman2099ESR1Gain1.15 μM
OT_ER_ERaERa_1440KidneyHuman2099ESR1Gain0.89 μM
OT_ER_ERaERb_0480KidneyHuman2099|2100ESR1|ESR2Gain0.13 μM
OT_ER_ERaERb_1440KidneyHuman2099|2100ESR1|ESR2Gain0.79 μM
OT_ER_ERbERb_0480KidneyHuman2100ESR2Gain0.03 μM
OT_ER_ERbERb_1440KidneyHuman2100ESR2Gain0.03 μM
OT_ERa_GFPERaERE_0120CervixHuman2099ESR1Gain0.07 μM
OT_ERa_GFPERaERE_0480CervixHuman2099ESR1Gain0.03 μM
OT_FXR_FXRSRC1_1440KidneyHuman6714|9971SRC|NR1H4Gain12.79 μM
OT_ER_ERaERa_0480KidneyHuman2099ESR1Gain0.33 μM
OT_ER_ERaERa_1440KidneyHuman2099ESR1Gain0.31 μM
OT_ER_ERaERb_0480KidneyHuman2099|2100ESR1|ESR2Gain0.19 μM
OT_ER_ERaERb_1440KidneyHuman2099|2100ESR1|ESR2Gain0.24 μM
OT_ER_ERbERb_0480KidneyHuman2100ESR2Gain0.08 μM
OT_ER_ERbERb_1440KidneyHuman2100ESR2Gain0.1 μM
OT_ERa_GFPERaERE_0120CervixHuman2099ESR1Gain0.1 μM
OT_ERa_GFPERaERE_0480CervixHuman2099ESR1Gain0.13 μM
OT_ER_ERaERa_0480KidneyHuman2099ESR1Gain0.46 μM
OT_ER_ERaERa_1440KidneyHuman2099ESR1Gain0.46 μM
OT_ER_ERaERb_0480KidneyHuman2099|2100ESR1|ESR2Gain0.14 μM
OT_ER_ERaERb_1440KidneyHuman2099|2100ESR1|ESR2Gain0.14 μM
OT_ER_ERbERb_0480KidneyHuman2100ESR2Gain0.09 μM
OT_ER_ERbERb_1440KidneyHuman2100ESR2Gain0.11 μM
OT_ERa_GFPERaERE_0120CervixHuman2099ESR1Gain0.12 μM
OT_ERa_GFPERaERE_0480CervixHuman2099ESR1Gain0.12 μM
OT_ER_ERaERa_0480KidneyHuman2099ESR1Gain0.32 μM
OT_ER_ERaERa_1440KidneyHuman2099ESR1Gain0.39 μM
OT_ER_ERaERb_1440KidneyHuman2099|2100ESR1|ESR2Gain0.15 μM
OT_ERa_GFPERaERE_0480CervixHuman2099ESR1Gain0.1 μM
TOX21_ARE_BLA_Agonist_ratioLiverHuman4780NFE2L2Gain13.37 μM

No ToxCast endpoints for intended target type: Cellular

No ToxCast endpoints for intended target type: Hormone
DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.