Trenbolone

• Identification
• Experimental evidence
• Physicochemical properties
• ADMET properties
• Descriptors
• Chemical-gene interaction
• Chemical-phenotype interaction
• Chemical-disease association
• ToxCast endpoints
• Associated AOPs
• Presence in consumer products
• Presence in chemical regulation or guideline
• Presence in human biospecimen

Literature identifier	Study type	Test dosage	Effective dosage	Endocrine-mediated endpoints	Systems-level perturbations
PMID:17822730	IVTH	0.025 mg/L	0.025 mg/L	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVTH	0.025 mg/L	0.025 mg/L	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:19241440	IVR	1.5 mg/kg	-	No significant effects observed	-
	IVR	40 mg/kg	40 mg/kg	Increased weights of accessory sex organs	Reproductive endocrine-mediated perturbations
PMID:29421751	IVTH	0.000000000001 - 0.0000001 M	0.00000000003 M	Cancer phenotype	Endocrine-mediated cancer
PMID:31869672	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.8 mg/kg/day	0.8 mg/kg/day	Affects steroidogenesis	Reproductive endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Affects anogenital distance	Reproductive endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
PMID:34243057	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Affects neuronal density	Neurological endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Changes in brain morphology	Neurological endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Affects neuronal signaling	Neurological endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Affects neural development	Developmental endocrine-mediated perturbations;Neurological endocrine-mediated perturbations
PMID:34627821	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Decreased testosterone levels	Reproductive endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Increase in T3 levels	Metabolic endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Changes in brain morphology	Neurological endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Impaired glucose tolerance	Metabolic endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Elevated glucose levels	Metabolic endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Affects liver function	Hepatic endocrine-mediated perturbations
	IVR	0.08 mg/kg/day	0.08 mg/kg/day	Affects metabolic rate	Metabolic endocrine-mediated perturbations
PMID:39481959	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Affects social behavior	Neurological endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decreased gonadotropin-releasing hormone (GnRH) levels	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decreased growth hormone (GH) levels	Developmental endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Lead to obesity	Metabolic endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Alters hypothalamic-pituitary-gonadal axis (HPG axis)	Neurological endocrine-mediated perturbations;Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Induce behavioral changes	Neurological endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Decreased estradiol levels	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Increased LH levels	Reproductive endocrine-mediated perturbations
	IVR	0.1 mg/kg/day	0.1 mg/kg/day	Affects expression of androgen receptor (AR)	Reproductive endocrine-mediated perturbations

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We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.