DEDUCT | Database of Endocrine Disrupting chemicals and their Toxicity profiles

Trenbolone

ToxCast endpoints for intended target type: RNA

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
LTEA_HepaRG_CYP2B6	Liver	Human	1555	CYP2B6	Inhibitory	1.14 μM
LTEA_HepaRG_CYP2E1	Liver	Human	1571	CYP2E1	Inhibitory	84.5 μM
LTEA_HepaRG_CYP3A4	Liver	Human	1576	CYP3A4	Inhibitory	0.46 μM
LTEA_HepaRG_CYP4A11	Liver	Human	1579	CYP4A11	Inhibitory	88.22 μM
LTEA_HepaRG_CYP4A22	Liver	Human	284541	CYP4A22	Inhibitory	88.19 μM
LTEA_HepaRG_GCLM	Liver	Human	2730	GCLM	Inhibitory	78.95 μM
LTEA_HepaRG_PEG10	Liver	Human	23089	PEG10	Inhibitory	0.8 μM
LTEA_HepaRG_SULT2A1	Liver	Human	6822	SULT2A1	Activatory	81.78 μM
LTEA_HepaRG_UGT1A1	Liver	Human	54658	UGT1A1	Activatory	1.0 μM

ToxCast endpoints for intended target type: Protein

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
ATG_AR_TRANS	Liver	Human	367	AR	Gain	0.22 μM
ATG_ERE_CIS	Liver	Human	2099	ESR1	Inhibitory	0.76 μM
ATG_AR_TRANS	Liver	Human	367	AR	Gain	0.06 μM
ATG_ERa_TRANS	Liver	Human	2099	ESR1	Gain	0.46 μM
ATG_ERE_CIS	Liver	Human	2099	ESR1	Activatory	1.64 μM
ATG_MRE_CIS	Liver	Human	4520	MTF1	Inhibitory	100.0 μM
ATG_ERa_TRANS	Liver	Human	2099	ESR1	Gain	0.33 μM
ATG_ERE_CIS	Liver	Human	2099	ESR1	Inhibitory	0.62 μM
ATG_p53_CIS	Liver	Human	7157	TP53	Inhibitory	100.0 μM
ATG_SREBP_CIS	Liver	Human	6720	SREBF1	Activatory	3.8 μM
ATG_AR_TRANS	Liver	Human	367	AR	Gain	0.01 μM
ATG_ERa_TRANS	Liver	Human	2099	ESR1	Gain	0.6 μM
NVS_NR_hER		Human	2099	ESR1	Loss	0.66 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	0.18 μM
NVS_NR_rAR	Prostate	Rat	24208	Ar	Loss	0.02 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	0.33 μM
NVS_NR_mERa		Mouse	13982	Esr1	Loss	2.67 μM
NVS_NR_rAR	Prostate	Rat	24208	Ar	Loss	0.01 μM
NVS_NR_hER		Human	2099	ESR1	Loss	0.05 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	0.05 μM
NVS_NR_rAR	Prostate	Rat	24208	Ar	Loss	0.0 μM
NVS_NR_rMR	Brain	Rat	25672	Nr3c2	Loss	0.24 μM
ATG_ERE_CIS	Liver	Human	2099	ESR1	Activatory	0.94 μM
ATG_IR1_CIS	Liver	Human	9971	NR1H4	Inhibitory	0.76 μM
ATG_Xbp1_CIS	Liver	Human	7494	XBP1	Activatory	134.49 μM
ATG_ERa_TRANS	Liver	Human	2099	ESR1	Gain	1.57 μM
BSK_BE3C_tPA	Lung	Human	5327	PLAT	Inhibitory	3.97 μM
BSK_CASM3C_IL8	Vascular	Human	3576	CXCL8	Inhibitory	4.42 μM
BSK_hDFCGF_PAI1	Skin	Human	5054	SERPINE1	Inhibitory	0.16 μM
BSK_LPS_Eselectin	Vascular	Human	6401	SELE	Inhibitory	4.36 μM
BSK_LPS_TNFa	Vascular	Human	7124	TNF	Inhibitory	5.85 μM
BSK_SAg_CD38	Vascular	Human	952	CD38	Inhibitory	4.62 μM
NVS_ADME_hCYP2C19		Human	1557	CYP2C19	Loss	5.75 μM
NVS_GPCR_gLTB4	Spleen	Guinea pig	100379538	Ltb4r	Loss	2.88 μM
NVS_NR_hAR		Human	367	AR	Loss	0.01 μM
NVS_NR_hGR		Human	2908	NR3C1	Loss	0.6 μM
NVS_NR_hPR		Human	5241	PGR	Loss	0.0 μM
NVS_NR_mERa		Mouse	13982	Esr1	Loss	2.38 μM
NVS_NR_rMR	Brain	Rat	25672	Nr3c2	Loss	0.07 μM
NVS_NR_hAR		Human	367	AR	Loss	0.0 μM
NVS_NR_hER		Human	2099	ESR1	Loss	0.44 μM
NVS_TR_rSERT	Brain	Rat	25553	Slc6a4	Loss	5.66 μM
CCTE_Simmons_AUR_rTPO	Thyroid gland	Rat	54314	Tpo	Loss	6.65 μM
ATG_hAR_XSP1	Liver	Human	367	AR	Gain	0.0 μM
CCTE_GLTED_hDIO2		Human	1734	DIO2	Loss	100.0 μM
ATG_hAR_XSP2	Liver	Human	367	AR	Gain	0.0 μM
ATG_hTRb_XSP2	Liver	Human	7068	THRB	Gain	0.03 μM
TOX21_AR_BLA_Agonist_ratio	Kidney	Human	367	AR	Gain	0.0 μM
TOX21_AR_LUC_MDAKB2_Agonist	Breast	Human	367	AR	Gain	0.0 μM
TOX21_ERa_BLA_Agonist_ratio	Kidney	Human	2099	ESR1	Gain	1.22 μM
TOX21_ERa_LUC_VM7_Agonist	Breast	Human	2099	ESR1	Gain	0.02 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	1.73 μM
TOX21_AR_LUC_MDAKB2_Agonist_3uM_Nilutamide	Breast	Human	367	AR	Gain	0.01 μM
TOX21_ERb_BLA_Agonist_ratio	Kidney	Human	2100	ESR2	Gain	0.7 μM
TOX21_PR_BLA_Agonist_ratio	Kidney	Human	5241	PGR	Gain	0.14 μM
TOX21_PR_BLA_Antagonist_ratio	Kidney	Human	5241	PGR	Loss	0.01 μM
TOX21_ERa_LUC_VM7_Agonist_10nM_ICI182780	Breast	Human	2099	ESR1	Gain	0.94 μM
TOX21_ERa_BLA_Agonist_ratio	Kidney	Human	2099	ESR1	Gain	1.27 μM
TOX21_ERa_LUC_VM7_Agonist	Breast	Human	2099	ESR1	Gain	0.11 μM
TOX21_GR_BLA_Antagonist_ratio	Cervix	Human	2908	NR3C1	Loss	3.38 μM
TOX21_ERb_BLA_Agonist_ratio	Kidney	Human	2100	ESR2	Gain	1.67 μM
TOX21_ERa_LUC_VM7_Agonist_10nM_ICI182780	Breast	Human	2099	ESR1	Gain	3.04 μM
TOX21_PR_BLA_Followup_Agonist_ratio	Kidney	Human	5241	PGR	Gain	0.29 μM
TOX21_PR_LUC_Followup_Agonist	Kidney	Human	5241	PGR	Gain	0.0 μM

ToxCast endpoints for intended target type: Molecular messenger

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
CEETOX_H295R_ANDR	Adrenal gland	Human	367	AR	Inhibitory	90.14 μM
CEETOX_H295R_CORTIC	Adrenal gland	Human	2908\|4306	NR3C1\|NR3C2	Inhibitory	3.19 μM
CEETOX_H295R_ESTRONE	Adrenal gland	Human	2099\|2100	ESR1\|ESR2	Activatory	83.15 μM
CEETOX_H295R_PROG	Adrenal gland	Human	5241	PGR	Activatory	0.1 μM
CEETOX_H295R_TESTO	Adrenal gland	Human	367	AR	Activatory	83.49 μM

ToxCast endpoints for intended target type: Pathway

Assay Name	Tissue	Organism	Target Gene ID	Target HGNC Symbol	Response	AC50 Value
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_Agonist	Bone	Human	367	AR	Gain	0.0 μM
UPITT_HCI_U2OS_AR_TIF2_Nucleoli_Cytoplasm_Ratio_Agonist	Bone	Human	367	AR	Gain	0.0 μM
ACEA_ER_80hr	Breast	Human	2099	ESR1	Gain	0.01 μM
ACEA_ER_80hr	Breast	Human	2099	ESR1	Gain	0.02 μM
ACEA_ER_80hr	Breast	Human	2099	ESR1	Gain	0.0 μM
OT_AR_ARELUC_AG_1440	Ovary	Chinese hamster	367	AR	Gain	0.0 μM
OT_AR_ARSRC1_0480	Kidney	Human	367\|6714	AR\|SRC	Gain	0.18 μM
OT_AR_ARSRC1_0960	Kidney	Human	367\|6714	AR\|SRC	Gain	0.03 μM
OT_AR_ARELUC_AG_1440	Ovary	Chinese hamster	367	AR	Gain	0.21 μM
OT_AR_ARSRC1_0480	Kidney	Human	367\|6714	AR\|SRC	Gain	0.03 μM
OT_AR_ARSRC1_0480	Kidney	Human	367\|6714	AR\|SRC	Gain	0.0 μM
OT_AR_ARSRC1_0960	Kidney	Human	367\|6714	AR\|SRC	Gain	0.0 μM
OT_ER_ERaERb_1440	Kidney	Human	2099\|2100	ESR1\|ESR2	Gain	0.16 μM
OT_ER_ERbERb_0480	Kidney	Human	2100	ESR2	Gain	0.37 μM
OT_ER_ERbERb_1440	Kidney	Human	2100	ESR2	Gain	0.2 μM
OT_ERa_GFPERaERE_0480	Cervix	Human	2099	ESR1	Gain	0.22 μM
ACEA_AR_agonist_80hr	Prostate	Human	367	AR	Gain	0.0 μM
TOX21_ARE_BLA_Agonist_ratio	Liver	Human	4780	NFE2L2	Gain	6.78 μM

No ToxCast endpoints for intended target type: Cellular

No ToxCast endpoints for intended target type: Hormone

DISCLAIMER

We have built a comprehensive resource which compiles potential endocrine disrupting chemicals (EDCs) based on the observed adverse effects or endocrine-mediated endpoints in published experiments on humans or rodents to support basic research. We are not responsible for any errors or omissions in the published research articles or supporting literature on potential EDCs compiled in this resource. Users are advised to exercise their own judgement on the weight of evidence for potential EDCs compiled in this resource. Importantly, our sole goal to build this resource on potential EDCs is to enable future basic research towards better understanding of the systems-level perturbations upon chemical exposure rather than influencing regulatory advice on chemical use.